Abstracts

Potential of Plasma Rich in Growth Factors (PRGF) for in situ regenerative medicine: progress in anti-aging medicine

Plasma rich in growth factor (PRGF) technology involves the use of patient’s own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. This technology provides a new approach for the stimulation and acceleration of healing and tissue regeneration. The versatility and biocompatibility of using patient-derived fibrin scaffold as an autologous, biocompatible and biodegradable drug delivery system opens the door to a personalized medicine that is currently being used in numerous medical and scientific fields including dentistry, oral implantology, orthopaedics, ulcer treatment, and skin regeneration among others. The present conference discusses the state of the art and new directions in the use of this endogenous technology in anti-aging ...medicine.

No Abstract Currently Available. Please check closer to the Congress Date.

Hormones are cellular messengers, conducting multiple roles in the maintenance of quality of life. From the 40 years onwards, human beings, in general, present a progressive decrease in synthesis and action of the sex hormones, precipitating morphological and functional changes that will eventually lead to the consolidation of greater deposition of central fat, favoring risk of obesity, diabetes and cardiovascular disease. A discussion, based on my clinical practice, will be provided on the prevention of the metabolic syndrome through the use of bio-identical hormones.

The biological aging can be defined as the progressive loss of optimal body functions as a result of intrinsic factors .This decline continues until the end of life. Although there are several hypotheses that attempt to explain the causes of aging, only a few are widely accepted, which does not mean they are correct. Among them, the theory of Harman , is 50 years-old and it is continuously revised revised . Thi theory postulates that the macromolecular damage induced by reactive oxygen species (ERO) is the main causal factor of aging and related diseases. These ERO are formed during the normal metabolism, primarily in detoxification reactions mediated by the microsomal cytochrome P-450 and in the electrons chain within the mitochondria. In addition, there are several exogenous sources of oxidative stress. In order to control the aging process, both sources of oxidants must be minimized. A few strategies to ...reach this goal will be presented.

No Abstract Currently Available. Please check closer to the Congress Date.

External ultrasound-assisted liposuction (XUAL)

Stella Obasanjo the First Lady of Nigeria from 1999 until her death in 2005, died a few weeks before her 60th birthday from complications of liposuction at a private health clinic in Puerto Banús, Marbella, Spain, on 23 October 2005. The surgeon, identified only as “AM“ in court, was sentenced to one year of imprisonment in September 2009 on a charge of “causing homicidethrough negligence“, disqualified from medicine for a period of three years and ordered to pay€120,000 (approximately US$176,000) in compensation to Stella Obasanjo`s son.
The physician had misplaced a tube designed for a liposuction procedure into Obasanjo`s abdominal cavity. She sustained a punctured colon and lacerated liver and died two days after the surgery.
Often used in conjunction with other plastic surgery techniques, liposuction ...removes pockets of fat from troublesome areas such as the thighs, hips, abdomen, and upper arms. Liposuction procedures vary depending on what your ultimate cosmetic goal is, and whether you are combining liposuction with other plastic surgery procedures.Simply put, liposuction is the surgical removal of fat cells through a stainless steel suction tube called a cannula. Like any plastic surgery, liposuction carries some amount of risk. Although liposuction complications are rare, they can include infection, nerve damage, seizures, and negative reactions to anesthesia. The most effective way to minimize your risk is to have a thorough physical examination prior to liposuction surgery. There is also the risk of experiencing adverse side effects, such as bruising and scarring.
To avoid this kind of problems we are actually doing  XUAL (External ultrasound-assisted liposuction). XUAL is a type of UAL (Ultrasound-assisted liposuction ) where the ultrasonic energy is applied from outside the body, through the skin, making the specialized cannula of the standard UAL procedure unnecessary. It was developed because surgeons found that in some cases, the UAL method caused skin necrosis (death) and seromas, which are pockets of a pale yellowish fluid from the body, analogous to hematomas (pockets of red blood cells).XUAL is a possible way to avoid such complications by having the ultrasound applied externally. It can also potentially cause less discomfort for the patient, both during the procedure and afterwards; decrease blood loss; allow better access through scar tissue; and treat larger areas. We are actually using a machine that combines XUAL with Radio Frequency, with a technology designed exclusively for cosmetic use.The heat produced by the system causes instant tightening of collagen and increases collagen production in the dermis.The treatment is ideal for face and neck remodelling, tightening and lifting flaccid areas of the face, reduce wrinkles, increase luminosity of the skin, body remodelling and cellulites, tightening areas of loose skin on the body, cellulite on arms, thighs, abdomen and bottocks. All this procedure can be seen in the 9 minutes video I will show today.

A capacidade de regeneração cutâneo do nosso organismo através dos mecanismos homeostáticos, é utilizada através da utilização dos factores de crescimento epiteliais potenciada pela capacidade de indução de colágenio que a técnica de micro agulhas permite. A terapia com Plasma Rico em Plaquetas aplicada com micro agulhas no conceito RIMA, permite-nos ter uma técnica minimamente invasiva no tratamento de flacidez, rugas, estrias, alopécia melasma, em qualquer zona do corpo, qualquer tipo de pele e em qualquer época do ano.

FINESS IN BLEPHAROPLASTY 

World Health Organization establishes as a health concept the complete physical, mental and social well-being.

The association of Oculoplastics & Aesthetical Medicine carries out a medicine program of preventive, healing and facial rehabilitation.

In that context, the oculoplastics’ surgeon assumes ocular aesthetics health both with responsibility and quality, under the scientific, ethic, and legal veil, which must guide its performance.

Among the most performed and beautiful surgeries in Oculoplastics, the Blepharoplasty is pointed out. That cosmetic eyelid surgery usually lasts for 1 to 2 hours, and is carried out with local anesthesia and sedation.

BEYHOND HORMONAL TREATMENTS FOR CLIMACTERIC WOMEN
 
The climacteric woman is an aging woman. As such, our most important objective is to prevent biological aging from exceeding her chronological age,
thus giving her better quality of life to her coming years and  more years to live, free from preventable diseases.
Other than hormonal treatments there are today proven strategies that prevent the shortening of the chromosomal telomeres, the markers of biologic aging.
Special attention must be paid to a good quality of life, exercise to combact sedentarism, a proper nutrition, tabagism abstention, quality of sleep, among many others.

Along the time the organism looses energy and the capability of regeneration. An accelerated blockage of the regeneration capability, due to several factors as chronical infections, environmental contamination, way of life, and food, becomes in a premature aging, with a diminish of the quality of life.

Anti aging medicine tries of obtain a lasting maintenance or restablishing the vitality levels (verified by several age parameters). We talk about the recovery or improvement of the biological functions or about we call Vitality.

We use the word vitality thinking about energy, so that the anti aging treatments have the capability of revitalizing and giving energy.

From our born we are heading to biological enthropy, that is, aging and dead. We understand the enthropy as the amount of degraded energy that cannot be used.
With the reduction of enthropy, a decrease ...of defensive systems appears a decrease of the capability of regeneration.

A dietary supplement is the most important in the therapies of anti-aging medicine.

The National Academy of Sciences published three studies about the aging effects than can be partially reverted with the combination of L carnitine and lipopic acid (Hagen et al, 2002), One of these studies inform us that the supplementation of these two nutrients provokes a partial improvement in the function decline of the mythocondrial membrane although the oxygen consumption was increasing.. Lipoic acid with acetil L carnitina improves the walking activity.
Aged human are characterized by lethargy, weakness and diseases and the supply of these nutrients gives antiaging measurable effects.

To obtain a good result, we must know the biological-biochemical status of the patient, to understand his meaning, to correct habits, way of life and to supply the appropiated nutrients with antioxidant, regenerated and energyzer capabilities.

I let myself to understand the meaning because sometimes we are guided by the simplicity without searching a cause.
We should remember that among the different therapies used in antiaging medicine, it is founded the energy therapies based on supplements as coenzyme Q10, carnitine, B complex, D Ribose, ATP, piruvate A. Therapies that we will talk about them in our meeting.

Dr. A. Marco Chover
Licenciado en Medicina y Cirugía por la Universidad de Valencia, 1982.
Vicepresidente ECPM (Consejo Europeo para la Pluralidad Médica
Miembro de la Sociedad Internacional de Medicina Ortomolecular
Miembro de ACAM (Colegio Americano de Medicina Avanzada
Miembro de la Sociedad Internacional de estudios proteomicos, Bruselas

No Abstract Currently Available. Please check closer to the Congress Date.

Combined chemical and brain stimulation induction of neurogenesis in brain injury and brain degeneration of aging

Current science elucidates several consequences of normal metabolism that are major determinants of aging damage to brain function; uncontrolled oxidation, chronic inflammation, and glycation. These consequences are influenced by several exogenous chemicals; R+ lipoic acid, turmeric, acetyl-L carnitine, cytidine-diphosphate choline, N-acetyl cysteine, idebenone, docosahexaenoic acid, L carnosine, and nicotine-adenine-dinucleotide hydrogen, which may inhibit cortical damage, and facilitate neurogenesis in both hippocampus and subventricular zone.
Computer stimulated hormesis of brain function facilitates fMRI verified neural plasticity and cognitive improvement, and may be obligatory for recovery of lost function. Specific physical exercise also facilitates neurogenesis. ...Combined chemical, computer stimulation, and exercise protocols offer stronger manipulation than single interventions alone. Combination protocols are discussed with reference to cases of traumatic brain injury and senility, and use of cognition testing and DTI MRI with tractography to verify neurogenesis.

Nutrigenomics and Personalized Nutrition – Science and Concept

Nutritional Genomics studies the interaction of food and its components with the human genome, in a molecular, cellular, and systemic level. Its main objective is to use diet, for preventing or treating disease.
In the nutritional genomics there are two terms used: Nutrigenetics, and Nutrigenomics.
Nutrigenetics studies the effect of the genetic variation, in the interaction within diet and disease. This includes the identification and characterization, of the genetic variants associated to different responses to nutrients. Its main objective is to make recommendations concerning the risks and benefits of specific diets, or isolated dietetic components. It is also called personalized or individualized nutrition.
The potential benefits of harnessing the power of genomics for dietary prevention ...of disease are enormous, and this is the approach being considered for the future of nutrition research in the posgenomic era.
The genomics revolution has catapulted development of various new technologies that can be applied to nutritional science.
The techniques, genomics, proteomics, metabolomics and bioinformatics are beginning to stand out to facilitate the study of gene-nutrient interactions at cellular, personal and in the population.
Nutrigenomics is the study of the effects of foods and food constituents on gene expression, and studies the effect of nutrients over the genoma, proteoma, and metaboloma.
Nutrigenomics is about how our DNA is transcribed into mRNA and then to proteins and provides a basis for understanding the biological activity of food components. Nutrigenomics has also been described by the influence of genetic variation on nutrition by correlating gene expression or single-nucleotide polymorphisms with a nutrient`s absorption, metabolism, elimination or biological effects. By doing so, Nutrigenomics aims to develop rational means to optimize nutrition, with respect to the subject`s genotype. By determining the mechanism of the effects of nutrients or the effects of a nutritional regime, Nutrigenomics tries to define the causality -relationship between these specific nutrients and specific nutrient regimes (diets) on human health.
Nutrigenomics has been associated with the idea of personalized nutrition based on genotype, and so act in an innovative preventive pathway through nutrition.

Bone regeneration and its impact in Anti-aging

Bone plays a key role in the support of Face soft tissues. Therefore bone loss in the face, mostly due to loss of teeth, represents a major factor of premature aging. Bone grafts were for a long time the unique reliable option to substitute atrophic or absent bone. For the past decade the industries investment in developing Biomaterials as bone substitutes represents a major tool in bone regeneration. The author speaks about the various options concerning both bone grafts and biomaterials in face bone regeneration and the impact they may represent in anti ageing medicine.

Organic Cosmetics Vs natural or conventional Cosmetics: principal constituints investigated for potential dangerous efects on human health and alternatives in Organic Cosmetics

Many of today’s beauty products are made up of varying mixtures of synthetically produced chemicals and these chemicals vary in their ability to penetrate the skin. Some are absorbed in small amounts, while some easily reach the blood vessels below the skin and are transported around the body. Conventional cosmetics have a lot of these synthetically produced chemicals, permited by law, while some natural products may contain very small amounts of these ingredients, what is concern for us and many others is the cumulative effect of applying various products regularly. Many chemicals found in cosmetics do not cause obvious immediate signs of toxicity, but might slowly damage us through repeated use on our skin and we ...have grave concerns over the long term effects this may have on our bodies. Many drugs on the market today are administered through transdermal skin patches, which have been shown to be very effective. This demonstrates that the skin, the largest organ of the body and our first line of immunity, absorbs products and their ingredients. So if you put it on your skin, you can safely say you have eaten it! And all these were the main reasons of the organic cosmetics development. There are currently no laws to guarantee that health and beauty care products labelled as natural don´t contain these chemicals or even a product labelled organic are indeed organic. EU organic regulations only cover farming and food production.
Over the last few years there have been certain cosmetic ingredients that have been highlighted in the media due to their links with health scares, which has led some people to choosing organic as a safer alternative. A certified Organic Product offers you the reassurance that all of the ingredients are safe for you and your family. In addition people that suffer from sensitive skin or conditions such as eczema or psoriasis report that organic skin care products work better for them as they contain either tiny amounts of synthetic chemicals, or no synthetic chemicals at all.
So, what to search for? The safer way to choose a cosmetic without these chemical substances are seek for a product that has been independently verified as organic. The standards also contain criteria that means ingredients must be assessed to not be harmful to human health and their manufacture and use must cause minimum environmental impact. The standards are based on principles that require the maximum amount of organic ingredients, minimum synthetic ingredients, minimum processing of ingredients and clear labelling so that you can make an informed choice about the product you are purchasing.To be organic can not used: Artificial Colours or Fragrances, GM Ingredients, Dioxins, Petrochemicals, Mineral Oils, Parabens, Animal derivatives, Imidazolidinyl Urea, Propylene Glycol, Petrolatum, Hexane, Phthalates, Sodium Lauryl Sulfate or Sodium Laureth Sulfate, Aluminium & Animal Derived Ingredients. The strength of the certification lies not only in what you must include (Organic ingredients), but also what you may not use.
But then comes out other big issue: manufacture problems. How to preserve the products, how to keep nice textures or strong smell? Some alternatives can be presented and their limitations too. Safest formulations and highest standards of quality without sacrifice the performance – the future path. Having the best of the 2 worlds.

ANTI-AGING ARTICULAR PROCESS

The author is going to discuss a new orthopaedic chapter which will involve 20 percent of the world population in 2020, 60 million people will be over 65 years old.
This situation will increase the vulnerability of the musculoskeletic system, as osteoarthritis of the knee and ankle, will affect 40-60 percent of the population.
To maintain good articular health we have sysadoas, where we include glucosamine, condrotine and hyloronic acid. Glucosamine and condrotine contribute to the cellular protection, condrocit protection and maintenance of the structural support of the cartilage. The hyloronic acid concentration of the synovial liquid is diminished, so that the visco supplementation treatment begins to be important.
This process consists of a series of intra articular injections with the objective of improving the quality, the lubrification and ...the shock absorbance.
The authors revise the recent concepts and therapeutic forms whose goal is to prevent and treat the anti-aging articular process.
Finally, we will discuss articular reconstruction surgery as the last concept of quality of life

Inflammatory hormones and pathological aging-a new global concept

The aging process remains unknown in great part, despite some partial advances in medical research. We need a new macroscopic perspective of this infinite complexity that may integrate several theories and the actual knowledge and find the Arianne String of the pathological aging process, so we may develop new effective anti-aging treatments of the real causes instead of the actual multiple symptomatic treatments.
This presentation analyses the several stages of the metabolic syndrome and the inflammatory hormones as its biochemistry basis, first related with high carbohydrates intake of our current diet, then related to weight excess in the thirties(fat is the main inflammation hormones producer) and highly aggravated in the forties by sleep breathing disorders, not only sleep obstructive apnea, but including snoring, ...upper airways resistance syndrome due to laxity of the oropharinx muscle walls with aging.
We emphasize the chronic pro-inflammatory state of the forty and fifty decades and the central role of the inflammatory hormones in the physiology of pathological aging, as cardiac dysfunction, drowsiness and fatigue, arterial hypertension and the higher levels of aldosterone causing renal, hepatic and cardiac fibrosis, night brain edema and headache, the role of night chronic facial edema and eritrasma in facial flaccidity including blepharochalasia, the arthrosis and a possible explanation of higher number of cancer cases in aging due to high level of inflammatory hormones.
We analyse the new perspectives of anti-aging treatment based in this new inflammatory paradigm- the surgical treatment of snoring, sleep apnea, the use of aspirin , non steroid anti-inflammatory drugs, omega 3, the possible new use of propanolol, the role of diet and muscle exercises in avoiding metabolic syndrome, lowering the inflammatory hormones levels so we may have a healthy aging. The refocusing of the inflammatory hormones as the central key of the pathological aging can lead to new paradigms in the treatment and real prevention of the diseases related to aging process, overcoming the current dogma of fatality and impotency.

No Abstract Currently Available. Please check closer to the Congress Date.

It may seem premature to be discussing the elimination of human aging as a cause of death, when so little progress has yet been made in even postponing it. However, two facts undermine this assessment. The first is that aging happens throughout our lives but only causes ill-health after middle age: this shows that we can postpone that ill-health without knowing how to prevent aging completely, but instead by molecular and cellular repair. The second is that the typical rate of subsequent, incremental refinement of big technological breakthroughs is usually fast enough (so long as public enthusiasm for them is strong) to change those technologies almost beyond recognition within a natural human lifespan. In this talk I will explain, first, why therapies that can add 30 healthy years to the remaining lifespan of typical 60-year-olds may well arrive within the next few decades, and, second, why those who ...benefit from those therapies will very probably continue to benefit from progressively improved therapies indefinitely and will thus avoid debilitation or death from age-related causes at any age.

Revitalisation and Mesotherapy with new techniques that give a “flash effect“ to the skin of  the face, neck, decolte and hands, with immediate results of the surface. Discussion of the “nappage“ procedure to get a natural appearance.

Dr. Sergio Klepacz: Psychiatrist, currently practicing in the Hospital Samaritano and in his private clinic in Sao Paulo. Master in psychopharmacology by the Federal University of Sao Paulo. Specialized courses in orthomolecular and antiaging medicine on FAPES Sao Paulo and author of two books: “Uma questao de equilibrio“ and “ Equilibrio hormonal e qualidade de vida“ that support hormonal and food supplementation therapy for emotional desorders.

The hippocampus, as the major role between emotional stability and longevity.
In his research  following personality traits and longevity, Terracciano, concluded after 50 years continuous that the individual  emotionally stable, active and conscious,  live on avarage of 2-5 years more than those who are not. Depression, is now a days, considered a major risk factor for death. In 1988, Peter Sterling and Joseph Eyer concluded that lost ...of cortisol release control due to stressful life, are associated with tipical aging deseases . Hippocampus is involved in the acquisition of new memories, neurogenesis, cortisol release and his malfunction , is associated with severe depression symptoms.
Several hormones and neurotransmissors are responsible for the good function of the hippocampus, which can be the key structure to understand the connection between hormones replacement therapy, nutritional supplementation, antioxidants, antidepressives drugs, life style and healthy longevity.

Evolutionary aspects of healthy eating
Lindeberg S. Dept of Primary Health Care Research, Lund University, Sweden staffan.lindeberg@med.lu.se

Abstract: Increasing evidence suggests that the relative intake of fat, carbohydrate and protein is of limited importance in the prevention of common Western diseases. Cardiovascular health has been excellent among non-western populations consuming vastly different proportions of macronutrients, as illustrated by Eskimos (low-carb) and Pacific Islanders (high-carb). During human evolution, meat-to-plant ratio and macronutrient composition must have varied considerably, with intakes often exceeding the limits suggested in any particular dietary model based on macronutrients. In contrast, Western people acquire 70 % or more of dietary calories from foods that were practically unavailable during human evolution, mainly cereals, dairy ...products, refined sugar, fats and oils.
In animal experiments, atherosclerosis is promoted not only by dietary fat (any type) but also by bioactive substances from grains (e.g. lectins) and milk (e.g. casein). In our own research, we have found an ancestral diet based on vegetables, fruit, root vegetables, lean meat, fish, eggs and nuts to be satiating and effective against the metabolic syndrome in humans and pigs.
Hence, ancestral diets may be the optimal choice for prevention and treatment of age-related degenerative western diseases, including cardiovascular disease, diabetes, obesity, insulin resistance, hypertension, dyslipidaemia, age-related dementia and some forms of cancer.

Reference. Lindeberg S. Food and Western Disease. Health and Nutrition from an Evolutionary perspective. Wiley-Blackwell, 2009.

No Abstract Currently Available. Please check closer to the Congress Date.

HOW NUTRIENTS CAN MODIFY GENE EXPRESSION

ReGENERA Research Group., Milano, Italy (www.regeneragroup.com) and WHO-cnt for Biotech & Trad. Med., University of Milano, Italy

Nutritional/nutraceuticals issues involved in any tentative prevention strategy are known to be the most important environmental epigenomic modifiers. Moreover, from the human genoma project conclusion, a post-genomic era has started, which represents an ideal match with tailored nutraceuticals, thus leading to a nutrigenomics evolution. Nutrigenomics mainly aims at studying genetic and epigenetic interactions with a nutrient as to lead to a phenotype change and therefore to the cell metabolism, differentiation or apoptosis. Such new nutraceutic perspective entirely depends on the growing development of new innovating solutions aiming at acting on organic systems. A biochemistry and molecular biology specific ...development together with biotechnological methods have been enhanced as to support the hypothesis that some nutrients could modulate the body functions. Such assessments has to be in line with consistent markers identification, both directly connected (functional factors) to the process to be modified as well as indirectly associated (indicators). This would play a definite role in general good health conditions as well as in the potential reduction of disease risk occurrence within a synergistic-integrated approach in established therapeutic regimens.

Genomics,Proteomics & Other “omics“ in Oncology

Pharmacogenomics, Transcriptomics, Genomics, Metabolomics, Interactomics, Immunogenomics, Genomics, Proteomics an other omics are currently more common nouns in the field of Biology and Medicine. We may consider that “..omics“ may be the comprehensive analysis of biological systems whether you are focusing your attention in DNA, RNA, Proteins, Metabolites or other molecules. Cancer development and progression is under the dependence of high complexity systems that may also influence the response to therapeutics an tumor behavior.Since we made the introduction of a Pharmacogenomics and Molecular Epidemiology Class in the Faculty of Medicine of Porto (2004) and in the Biomedical Sciences Institute (ICBAS, 2006) an increasing number of researc reports have  been published demonstrated the importance of the “omics“ research field in ...Cancer Biology and Oncology.A comprehensive review will be presented pointing more recent practical examples(Cancer Chemother Pharmacol.2009;Pharmacogenomics J. 2009 Oct;9(5):341-6;Exp Biol Med 2009 Mar;234(3):241-5;Eur J Gastroenterol Hepatol. 2009 Jan;21(1):76-91; DNA Cell Biol. 2008 Aug;27(8):415-21; Clin Cancer Res. 2008 Jun 1;14(11):3367-71;Cancer Genet Cytogenet.2008 May;183(1):35-40;DNA Cell Biol. 2008 Jun;27(6):333-6;Prostate Cancer Prostatic Dis. 2008;11(1):94-8;Gynecol Obstet Invest. 2007;64(4):208-12.;Breast Cancer Res Treat. 2008 May;109(1):183-5;Oncologist. 2007 Feb;12(2):201-10;Breast Cancer Res Treat. 2007 Jun;103(2):209-17;J Neurooncol. 2007 Feb;81(3):225-9;World J Gastroenterol. 2006 Aug 21;12(31):5033-6;Head Neck. 2006 Jul;28(7):603-8; Eur J Cancer. 2006 May;42(8):1188-93;Eur J Cancer. 2006 May;42(7):958-63.Eur J Clin Pharmacol. 2006 Jan;62(1):15-21;Biochem Biophys Res Commun. 2006 Feb 3;340(1):256-62;Cancer Immunol Immunother. 2006 Jun;55(6):639-43;Prostate. 2005 Aug 1;64(3):246-52.;Cancer Genet Cytogenet. 2004 Nov;155(1):42-6.;Angiogenesis. 2004;7(1):53-8; J Pathol. 2004 Mar;202(3):330-5;Int J Clin Oncol. 2003 Jun;8(3):156-61. Several new fields of research including stem cells may open new “omics“ in Oncology and other diseases.

No Abstract Currently Available. Please check closer to the Congress Date.

Orthomolecular Approach in Intestinal Disbiosis and Leaky Gut Syndrome

The Intestinal Microflora represents 80% of the human acquired immunity. In 400 m2 of Intestine, there are 2000 m2 of microscopic structures, 100 billions microbes, 500 distinct species. For 1012 human cells, we find 100 times more microorganisms. Medium to severe Disbiosis and Leaky Gut Syndrome with inflammatory recurrence is epidemic nowadays in most of the individuals. Understanding the balance and physiology behind the mucosal associated immunity and the microecolgy mechanisms is the key point to prevent and treat direct and indirect intestinal coming pathologies. The orthomolecular medicine approach of intestinal immunoregulation has been shown to be successful in the resolution of chronic Chron’s Disease, Inflammatory ...Bowel Disease, Atopic Dermatitis and Obesity. The correct use of molecular bioactive dietary supplements and probiotics is able to guarantee the best flora pH, metabolic vitamins synthesis, regulating oxidative stress associated hormones and IgE dependent histamine, increase the stimulation of s‐IgA, CD4 and CD8 T cells in immunosuppressive patients, induce the beneficial action of the Regulatry T‐Cells (Tregs) in autoimmune situations, shut off the transcriptional activation of the Tool‐Like Receptors and NF‐κβ, as well as correct the injured cell membranes due to inflammatory processes. The orthomolecular concept in anti‐ aging and functional integrative medicine is a valuable tool for doctors intending to give their patients the best natural life quality with less chemical adverse side effects intervention.

No Abstract Currently Available. Please check closer to the Congress Date.

No Abstract Currently Available. Please check closer to the Congress Date.

No Abstract Currently Available. Please check closer to the Congress Date.

Endothelial Dysfunction: accumulation of vascular risk factors and aging. the effect of anti-oxidants in the improvement of erectile function

1) Department of Biochemistry (U38/FCT), Faculty of Medicine of the University of Porto, Porto, Portugal
2)Laboratory for Molecular Cell Biology, Faculty of Medicine of the University of Porto, Porto, Portugal
3) iSEX, Association for the Advanced Study of Human Sexuality, Lisboa, Portugal

Metabolic disorders and oxidative stress are key correlates for the development of endothelial dysfunction and loss of erectile function. The deleterious actions of these factors promote the disruption of endothelial biological activities, causing endothelial malfunction. The endothelium plays a crucial role in systemic vasodilation and hemodynamic events, including the ones involved in erection physiology. Due to these ...relevant functions, a close link has been established between endothelial integrity, erectile dysfunction (ED) and cardiovascular disease (CAD). In fact, it is currently recognized that ED may be the first clinical manifestation of a generalized vascular disorder and should be considered as an alert for future cardiovascular events. Obesity, lipidic disorders, hypertension, diabetes and the associated excess in oxidative stress have been identified as key vascular risk factors (VRFs) for ED and CAD, having as common denominator generalized endothelial dysfunction. This link suggests by controlling VRFs, either through life changing habits or by the use of medications and/or supplements, endothelial and erectile function could be concomitantly improved. But can in fact endothelial health be recovered and ED ameliorated? Several studies have indicated that endothelial and erectile function may benefit at some extent from a reduction of VFRs and from a decrease in oxidative stress. However we must be aware that a persistent exposure to VRFs and reactive oxygen species, besides altering nitric oxide bioavailability/bioactivity, may abrogate other endothelial cell vital mechanisms, compelling them to enter programmed cell death. The severity of endothelial apoptosis may dictate if vascular regeneration may occur or if vascular deterioration may endure. In fact, recent studies from our group have shown for the first time a close link between endothelial apoptosis levels and ED in diabetic men. We provided evidence that established diabetes, promotes severe cavernosal endothelium dysfunction through the activation of the apoptotic process. Cavernosal tissue of diabetic patients with ED has increased endothelial apoptotic cell density (ACD), as compared to non-diabetic non-ED individuals. More importantly, ACD was shown to correlate with penile function assessed in a preoperative stage by the Penile NO Release Test (PNORT), allowing us to establish a threshold between ACD values and cavernosal endothelial functionality. Our results, besides supporting the crucial role of endothelial integrity in erection physiology, highlight to the benefits of early intervention measures to control VRFs. Additionally, we reinforce the importance of a throughout evaluation of endothelial health in ED patients in an earlier stage, before endothelial systemic disease is manifested.

Dermamelan is a professional depigmentation treatment. Very effective for melasmas imperfections and hyper-pigmentations.
After a month of application, the results are spectacular.
It is a combination of selected ingredients including different acids, which principal action is a reversible and non cytotoxic inhibition of the Tyrosinase, the core of the commun methabolic pathway of the melanins pigments synthesis. Since some other principles from the formula have not only a depigmentation indication; Dermamelan can also be considered as a complete anti-aging program with a visible improvement of wrinkles and flaccidit
As it is formulated in Mesostetic pharmaceutical laboratory, the concentration of the ingredients is very high. This fact allows a deep and effective penetration of actives which goal remains to reach the target, the melanocyte, and more precisely the melanosome where the ...melanin synthesis occurs, and so where the Tyrosinase acts .
But this is not the only way Dermamelan is going to work for the depigmentation purpose. Other methabolic vias of the pigment synthesis process are going to be blocked. Thanks to the synergic action of the substances from the exclusive formula of Mesoestetic, as well as the protocol of application makes the treatment ideal to avoid post inflammatory hyper-pigmentations.
The pack contains, two jars. The mask for a unique application and the daily maintenance treatment. In order to remove all impurities of the area to be treated, the pack also includes a specific cleansing.

Understanding the Controversy: Hormone Testing & Bio-identical Hormones

As we age we lose hormones. Women are the ones that suffer the most with this issue. Despite the general opinion, a wrong one, they begin loosing hormones by their middle thirties, and the most remarkable lost is undoubtedly of progesterone.
This being said, it is easy to understand that Progesterone is the key to a healthy peri-menopause, since it prevents osteoporosis, fibroids and breast cysts. Towards a solution, they are regularly given progestin, which causes even more health problems.
It is often forgotten that women do have testosterone, and that the lack of this hormone wrecks havoc their libido, skin and bones. The community seems to be afraid of hormones, though bio-identical hormones are around four million years and are perfectly safe, otherwise young women would have breast and uterine cancer! ...These hormones are ours; they couldn’t manage to be more natural indeed, although not profitable for big pharma. The key for bio-identical hormones replacement therapy is to mimic woman’s normal cycle, while listening to her body necessities’. This should give us a fair balance between what that specific woman needs and the estrogen replacement possible. Hormone testing is not only a possibility but an imperative medical need.
In conclusion, we must bear in mind that hormones are all interrelated, and that symptoms are the ones in charge in what comes to replacement therapy.

Innovative fractional laser skin resurfacing therapy

The fight against the indelible signs of aging has been the cornerstone of resurfacing laser treatments and the CO2 laser is one of its principal weapons. However, being one of the most effective treatments when it comes to evaluating the downtime and the side effects, which are temporary but quite uncomfortable, no one was satisfied and this led to an understandable refusal to undergo these techniques in the majority of patients.
That is how the brilliant contribution of fractioning emerged to improve the safety range that is lacking in the conventional ablative system. The reduced recovery time has been the key to making this fractioned treatment popular yielding more than satisfactory results if we wisely choose the patients susceptible to receiving this laser therapy. Likewise with light therapies, we can combine them with other ...techniques such as fillers and botulinum toxin and obtain even better and lasting results.
The formation of crusts is normal in all ablative treatments, but after fractioning, not only are they more even owing to the distribution of the laser impacts on the skin surface by means of a scanner, but the time necessary for the crusts to fall and the healing process is considerably reduced with a similar effect to the one when the system was continuous. Furthermore, moving around and walking is much easier post-treatment given that the exudation and bleeding are minimal if we compare it to other treatments in the past.

The Role of Hormones in Aesthetics – An Essential Component of Integrative Rejuvenation Medicine

Over 25 years of private practice, we have developed a unique integrative approach to aesthetic enhancement of our patients which encompasses a holistic model which we term Rejuvenation Medicine.  In this model, we incorporate components of surgical and non-surgical Facial and Body Aesthetics, conventional (western) and alternative (eastern) therapies, dietary and exercise counseling, allergy evaluation and desensitization, and nutritional/hormonal assessment and supplementation.  The use of bio-identical hormone supplementation assists in the functional support of our surgical procedures, reducing per-operative bruising and discomfort, supports longevity of our surgical results, and increases overall patient satisfaction with the procedures performed. This new integrative approach to the care ...of the patient seeking aesthetic enhancement has led to our development of a new approach to our practice specialty, namely Cosmetic Surgery and Rejuvenation Medicine. The various aspects of our unique practice model, “Beauty from the Inside Out”, will be discussed.

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The Intra-Areolar Multi-W-Plasty Approach to Breast Augmentation – RejuvENHANCE ™ :the “No-Skin-Scar” Technique

Multiple surgical approaches have been proposed for breast augmentation using implants: infra-mammary, axillary, trans-umbilical and peri-areolar.  Each of these techniques lead to scarring.  We developed a unique technique of breast augmentation that prevents all incisions of the skin proper and, therefore, prevents all scarring of skin.  We describe our 25 year experience with the intra-areolar multi-w-plasty technique. This technique, which places an accordion-shaped incision restricted to a natural wrinkle within the areola provides for optimal direct access to the surgical pocket, provides optimum placement of the implant, minimizes tissue trauma and results in a well-cammouflaged surgical incision site.

Insulin, Leptine and Cortisol, or the Nutrition, Exercise and Stress connection

A leptina, uma hormona libertada no tecido adiposo e cuja amplitude de funções só recentemente se conhece, modula o apetite através dos seus receptores específicos na hipófise.
Com um ritmo circadiano próprio, e dependente da melatonina, a leptina está sinergicamente relacionada com a insulina, nos metabolismo dos hidratos de carbono e lipogénese, e com o cortisol, na interacção neuropsíquica.
As alterações metabólicas conducentes à insulinoresistência entrecruzam-se com as da leptinoresistência e com os desequilíbrios dos níveis de cortisol.
A obesidade e a síndrome metabólica, evoluem a par de um apetite insaciável e de uma fadiga continuamente crescente.
Pela compreensão da conexão insulin - leptina – cortisol percebemos que a estratégia do seu tratamento e ...da manutenção do seu equilíbrio passa pela intervenção médica, pela nutrição, pelo exercício físico e pelo stress manegment, uma estratégia fundamental em Medicina Anti-aging.

No Abstract Currently Available. Please check closer to the Congress Date.

Conventional oncology aims at treating cancer by destroying tumor cells. Integrative Oncology also includes strategies to change the tumor`s micro-environment and to stimulate the body`s natural defenses against cancer growth. Genetics account for at most 15% of cancers. The rest can be attributed to a combination of life-style and environment. Harnessing new discoveries on the role of nutrition, physical activity, stress management and control of environmental contaminants can have a significant impact on cancer prevention, but also on slowing cancer growth and markedly improving survival as quality of life in patients already diagnosed with cancer. In view of the existing scientific evidence, modern oncology should include a combination of conventional treatments with integrative approaches.

Everyone knows the power of a beautiful smile. We are living very exciting times when it comes to what we can provide for our patients,their overall appearence and function.We have a vast array of  knew techniques ranging from surgical proceadures,implants,tissue regeneration,orthodontics to adhesive porcelain. We will discuss porcelain veneers,a very powerfull anti-aging tool, which can provide dramatic results with a minimally invasive technique. We´ll go through the basic steps involved in the “making of” and look at a number of before and after cases.

No Abstract Currently Available. Please check closer to the Congress Date.

No Abstract Currently Available. Please check closer to the Congress Date.

Insulin resistance (IR) it’s a condition where basal values of insulin are inadequate to produce a normal insulin response in skeletal-muscle, adipose tissue and liver cells. Insulin resistance in muscle cells reduces blood glucose clearance, whereas IR in liver cells causes impaired glycogen synthesis and a failure to suppress glucose production. These circumstances lead to a state of hyperglycemia, which leads to hyperinsulinemia which is believed to be one of the factors that contributes to the development of diabetes type 2, a condition that it’s increasing prevalent in modern societies. An increase in the concentration of insulin in the circulation stimulates the synthesis of triglycerides (lipogenesis) that can also be important to understand the epidemic of hypertrigliceridemia. Insulin also decreases lipolysis, the breakdown of fat for utilization by the organism, by direct action on hormones ...responsible for the hydrolysis of triglycerides to fatty acids. On the other hand, physical exercise (PE) is consensually accepted as an efficient strategy to prevent increases in body weight, fat mass accumulation and the development of chronic diseases. One of the mechanisms in which PE can help decrease risk factors for metabolic problems it’s due to adrenergic action in the organism. Exercise releases hormones: adrenalin, noradrenalin, thyroxin, testosterone, estrogens, and glucagon, which increases lipolysis, mobilizing fat stores in the skeletal muscle and in the adipose tissue releasing energetic substrates for oxidation needs. It is of the greatest importance for the success of an exercise program or an exercise intervention to control for the insulinemic state of the participant, either if it’s a clinical condition, or with a subject that it’s apparently healthy. The frequency, type and volume of the PE needs to be adjusted to the needs of the participant, not only in a macro-perspective (decrease in adipose tissue, decrease in glycemia), but also at the molecular level, in the action of enzymes and hormones that are associated with lipolysis and lipogenesis processes. Concurrently, the diet needs to be included in the “intention to treatment”, due to the deleterious effects that macronutrients, both in their quality and the quantity, have on the metabolic effects of PE.

THE OMEGA-6/OMEGA-3 RATIO IN HEALTH AND DISEASE

The Center for Genetics, Nutrition and Health
Washington, DC 20009 USA

Several sources of information suggest that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of ~1 whereas in Western diets the ratio is 15/1 – 16.7/1. Western diets are deficient in omega-3 fatty acids, and have excessive amounts of omega-6 fatty acids compared with the diet on which human beings evolved and their genetic patterns were established. Excessive amounts of omega-6 polyunsaturated fatty acids (PUFA) and a very high omega-6/omega-3 ratio, as is found in today’s Western diets, promote the pathogenesis of many diseases, including cardiovascular disease, obesity, diabetes, cancer, inflammatory and autoimmune diseases, and mental health, whereas increased levels of omega-3 PUFA (a lower ...omega-6/omega-3 ratio), exert beneficial effects. Studies on the mechanisms involved indicate that linoleic acid (LA) increases low-density lipoprotein oxidation and severity of coronary atherosclerosis and inhibits eicosapentaenoic acid (EPA) incorporation in the neutrophil membrane phospholipids of human subjects. Furthermore, decreasing LA with constant alpha-linolenic acid (ALA) in dietary fats increases EPA in plasma phospholipids in healthy men. In healthy subjects on a modified Mediterranean diet, lowering the omega-6/omega-3 ratio decreases vascular endothelial growth factor (VEGF), platelet activation, and tumor necrosis factor alpha (TNF-α), but increases adiponectin significantly as well as fatty acid oxidation. In transgenic animals the balanced omega-6/omega-3 fatty acid ratio decreases the risk for chronic diseases. Omega-3 fatty acids influence gene expression. Genetic variants in the 5-lipoxygenase gene promoter can trigger atherogenesis in humans at higher intake of omega-6 fatty acids whereas the effect of the gene variant is blunted in the presence of a high EPA and docosahexaenoic acid (DHA) dietary intake. A lower omega-6/omega-3 ratio is associated with decreased risk of many chronic diseases including cardiovascular disease, hypertension, arthritis, osteoporosis, cancer, neurodegenerative diseases, and various aspects of mental illness, violent behavior, and deficient cognition in both children and the elderly. The balance of omega-6 and omega-3 fatty acids is important for homeostasis and normal development throughout the life cycle. Because many chronic diseases are multigenic and multifactorial the therapeutic dose of omega-3 fatty acids will depend on the degree of severity of disease resulting from the genetic predisposition. The scientific basis for the development of public policy to develop dietary recommendations, including a balanced omega-6/omega-3 ratio, is robust.

Adrenal fatigue is a very common problem in our society today. However, it can present in many ways and has been called by many different labels. We will review the common presenting complaints, physical exam findings, appropriate laboratory work-up and treatment of adrenal fatigue. The critical analysis and prioritization of laboratory testing to acquire objective data on adrenal function will be discussed. In addition, we will learn to utilize diet, nutrients, phytonutrients, and hormone replacement to enhance adrenal function.

Endothelium, Erection and Coronary Arteries: the dilemma of the ageing male


Twenty five years ago we have clearly establish that erectile dysfunction (ED) was frequently linked to vascular risk factors ‘VRF) and that more VRF were present more likely ED will have an arterial origin. Thus ageing males smokers, obese, diabetics, suffering hypertension and/or excess of lipids are prone to have ED. Due to the particular hemodynamic of the penis needing to achieve quickly at the right moment full rigidity, even a very light reduction of the caliber of these small arteries shall reduce the amount of blood reaching the organ and cause ED. Obviously ED in patients with VRF or metabolic syndrome is an alarm symptom for further vascular diseases, namely coronary heart disease (CHD). We shall show how ED and CHD are twins and that early markers of the endothelium help to ...determine those who are at risk. By evaluating endothelial dysfunction soon when still reversible, we may prevent the evolution of this population from entering in the arteriosclerosis disease. This applies to the entire ageing population and even the younger one submitted to all the risks factors of the modern civilization.

Since the human genome sequence was deciphered, millions of genetic variations have been discovered and catalogued. Based on the common variant-common disease hypothesis, hundreds of thousands of genetic variants have been screened for their association with common chronic and complex diseases. In the past 2 years, a large number of genome wide association studies supported by advances in massive parallel genotyping have made it possible to provide more than 70 diseases susceptibility loci for several common diseases such as diabetes and cardiovascular diseases. 
However, translating these results into improved clinical diagnostic management still remains a challenge because of the complexity of the genetic factors underlying these diseases and the overwhelming environmental and lifestyle influences.
A large proportion of these disorders have been related to an oxidative stress increase and ...recent research has suggested a direct link between the predisposition to a disease such as prostate cancer, the SOD2 V16A genetic variation and oxidative stress (Kang D. et al., 2007). In this particular case, a precise measurement of oxidative stress can advantageously complement a genetic screening for this particular SNP and provide it with an enhanced risk assessment for prostate cancer. 
My research focus in the development of genetic test panels using the latest technological genotyping innovations. We therefore propose, in partnership with Edel Therapeutics - which has developed a new patented device for measuring the antioxidant capacity of biological fluids based on electron transfer - to combine genetic testing and the antioxidant capacity measurement as a new validation and research tool for oxidative stress related diseases. Such a multi-level approach will pave the way for the understanding of the interaction between genetic variation- oxidative stress - related diseases and a more accurate personalized medicine.

Promession

The conceptual idea is to combine biological knowledge with a dignified and ethically correct way of being remembered by ones next of kin. The primary principles are preservation after death in organic form and shallow burial in living soil that quickly converts us to mulch.

The fact that this way of thinking is contrary to many customs, yet we should try to adopt a more natural approach to our life and our death. Today`s burial traditions conceal reality from people and do not allow them to feel secure in the fact that death is essential to new life. 

 Deeper insights in ecology provide greater understanding of and respect for life on earth. With the knowledge of what happens to the body after death, it is Promessas hope that people will find greater security in their physical fate. This, in turn, can give our minds greater freedom to ponder the spiritual issues ...that we all carry within ourselves.